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Oxalobacter formigenes metabolizes oxalate as its sole carbon and energy source using the oxalate-formate antiporter (OxlT) and the formyl-CoA transferase/oxalyl-CoA decarboxylase pathway.
Kidney · LPB-UR-001
Lorbiotics · LPB-UR-001
Clinical DomainUrology / NephrologyLorbiotics CKD Forte
Advanced kidney support for those who need it most. Targets kidney stone prevention and supports CKD management by reducing uremic toxins.
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6Active strains
Capsule / SachetDosage form
- Capsules
- Allergen Free
- In Vitro Test
- Clinical Test
- 24 Month Stability
1
70%
The headline result
~70% reduction in recurrent calcium oxalate stone risk with O. formigenes recolonisation — the only probiotic with a dedicated oxalate-degrading pathway, reducing urinary oxalate by 70-80%.
The science
Why CKD Forte works.
CKDforte is a specialised nephrological synbiotic designed for the prevention and adjunct management of calcium oxalate nephrolithiasis - the most common kidney stone type (80% of cases).
Its cornerstone is Oxalobacter formigenes, the only gut bacterium with a dedicated role in oxalate breakdown. This makes CKDforte the first probiotic that directly targets the main driver of calcium oxalate stone formation.
Calcium oxalate stones form when high urinary calcium meets elevated oxalate (hyperoxaluria). Colonisation with O. formigenes reduces urinary oxalate by 70–80% and cuts recurrent stone risk by ~70%.
However, this beneficial bacterium is highly sensitive to antibiotics and is often depleted in patients with recurrent stones, IBD, or repeated antibiotic exposure - a key gap that CKDforte addresses.
Supporting ingredients include four proven probiotic strains (Bacillus coagulans, Lactobacillus plantarum, Lactobacillus acidophilus, Bifidobacterium bifidum) that correct urological dysbiosis, plus Inulin (prebiotic) that sustains O. formigenes colonisation and promotes short-chain fatty acid (SCFA) production to protect kidney cells from oxalate-induced damage.
Therapeutic targets
- 01Kidney stone prevention
- 02Calcium oxalate crystal inhibition
- 03Recurrence prevention
- 04Secondary oxalate degradation
- 05Urinary calcium management
- 06Renal tubular protection
“CKDforte is a specialised nephrological synbiotic designed for the prevention and adjunct management of calcium oxalate nephrolithiasis - the most common kidney stone type (80% of cases).”
Lorbiotics CKD Forte · Urology / Nephrology
Mechanism of action
How it works, step by step.
The documented biological pathway — exactly how each component acts inside the body.
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This degrades dietary oxalate in the gut before absorption, reducing urinary oxalate excretion by 70–80%. It also actively secretes oxalate from blood into the intestinal lumen via the Serum Oxalate-Lowering Factor (SOLF) mechanism, further lowering systemic oxalate load and urinary supersaturation.
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Bacillus coagulans and Lactobacillus acidophilus provide secondary oxalate-degrading support through oxalyl-CoA decarboxylase activity, serving as enzymatic backup during O. formigenes recolonization.
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Lactobacillus plantarum enhances small-intestine calcium absorption, reducing urinary calcium levels and thereby limiting calcium-oxalate crystal formation.
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Inulin selectively feeds O. formigenes and maintains the SCFA-rich anaerobic colonic environment essential for its sustained growth and activity.
Inside the formula
Every ingredient earns its place.
The exact composition of Lorbiotics CKD Forte — each organism and active listed at its formulated dose.
| Organism / active | Documented role | Dose |
|---|---|---|
| Oxalobacter formigenes | — | 5 B CFU |
| Bacillus coagulans | — | 3 B CFU |
| Lactobacillus plantarum | — | 2 B CFU |
| Lactobacillus acidophilus | — | 3 B CFU |
| Bifidobacterium bifidum | — | 2 B CFU |
| Inulin Prebiotic as standardized | — | — |
The practical bits
How to take it.
Dosage
1–2 sachets/capsules daily, with meals, for long-term maintenance. For post-antibiotic O. formigenes recolonisation: 2 sachets/capsules daily for the first 4 weeks. Or as advised by nephrologist / urologist / physician.
In the pack
Capsule / Sachet · 60 per Pack
With Inulin prebiotic to sustain O. formigenes colonisation. Take with meals; long-term use for stone prevention.
Certifications
- WHO-GMP
- ISO 13485
- Allergen Free
- Clinical Test
- 24 Month Stability
Note: Not for medicinal use or for curative action. Recommended to use as food supplement only
Reviews
What people say after they've actually taken it.
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Reviews come from verified buyers only. Once customers who've purchased CKD Forte share their experience, you'll see it here.
Evidence base
Peer-reviewed references.
Every claim on this page traces back to published literature. The full citation list for Lorbiotics CKD Forte.
- 01Siener R, et al. Kidney Int. 2013 83(6):1144-9.
- 02Probiotical S.p.A. LPB-UR-CKDFORTE · O. formigenes + B. coagulans + L. plantarum + L. acidophilus + B. bifidum 4B + Inulin · 60 Caps
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