01
Lactobacillus plantarum works in two main steps:
Skin · LPB-DE-004
Lorbiotics · LPB-DE-004
Clinical DomainDermatologyLorbiotics Atopic Forte
Advanced support for severe atopic dermatitis that doesn't respond to standard treatments. Targeting the deep immune dysregulation behind stubborn AD.
☆☆☆☆☆No reviews yet14BCFU at expiry · per dose
3Active strains
Capsule / SachetDosage form
- Capsules
- Allergen Free
- In Vitro Test
- Clinical Test
- 24 Month Stability
1
16W
The headline result
16-week minimum course recommended for moderate-to-severe AD — upstream NF-kB modulation by L. plantarum provides broader and longer-lasting immune rebalancing than single-cytokine blocking therapies.
The science
Why Atopic Forte works.
Lorbiotics-Atopic Forte is the premium, multi-strain dermatological probiotic in the Lorbiotics range, specifically developed for moderate-to-severe atopic dermatitis requiring a comprehensive, multi-mechanism approach.
It combines three clinically targeted strains - Lactobacillus plantarum, Bifidobacterium lactis, and Lactobacillus rhamnosus - with Riboflavin (Vitamin B2), a prebiotic, and a proprietary Phytoactivant blend.
This advanced formulation delivers synergistic benefits including immune modulation, antagonism of S. aureus, and enhanced skin barrier renewal.
Targeted Immune Action
Moderate-to-severe atopic dermatitis involves complex cytokine imbalance with excess Th2 (IL-4, IL-13), Th17 (IL-17, IL-22), and Th22 activity, driving inflammation, epidermal hyperproliferation, and barrier dysfunction.
L. plantarum counters Th2 dominance via IL-12 induction.
B. lactis modulates Th17 pathways through IL-10-mediated Treg promotion.
L. rhamnosus provides complementary Treg induction for sustained immune tolerance.
Riboflavin (Vitamin B2) Support
Riboflavin serves as a critical cofactor (FAD/FMN) for glutathione reductase, enabling continuous regeneration of reduced glutathione - the skin’s primary antioxidant defense.
Patients with chronic inflammatory skin conditions often show riboflavin deficiency; supplementation accelerates lesion resolution and supports skin recovery.
Lorbiotics-Atopic Forte offers a higher-complexity, multi-targeted solution for challenging atopic dermatitis cases.
Therapeutic targets
- 01Moderate-to-severe atopic dermatitis
- 02Staphylococcus aureus antagonism
- 03Skin renewal promotion
- 04Upstream immune rebalancing
- 05Antioxidant recycling
- 06Sustained immune tolerance
“Lorbiotics-Atopic Forte is the premium, multi-strain dermatological probiotic in the Lorbiotics range, specifically developed for moderate-to-severe atopic dermatitis requiring a comprehensive, multi-mechanism approach.”
Lorbiotics Atopic Forte · Dermatology
Mechanism of action
How it works, step by step.
The documented biological pathway — exactly how each component acts inside the body.
02
It activates natural suppressor proteins (A20 and IκBα) inside intestinal dendritic cells.
03
These suppressors block the NF-κB pathway, which then reduces the activity of two important master switches (GATA-3 and RORγt) in immune T-cells of the skin-draining lymph nodes.
04
Because it targets these upstream master regulators, L. plantarum creates a wider and longer-lasting balance in the immune system than medicines that only block single cytokines downstream. This is why it shows better results in patients with moderate-to-severe atopic dermatitis (AD).
05
Bifidobacterium lactis helps through two different actions:
06
It produces acetate, which lowers the pH in the intestine. This makes the gut less hospitable for Staphylococcus aureus, reducing the amount of bacteria that can travel from the gut through the blood and colonise the skin.
07
It activates EGFR signals in skin cells (keratinocytes). This boosts skin cell growth, movement, and maturation, helping to repair and rebuild the damaged skin barrier in AD.
08
Phytoactivants in the blend provide extra anti-inflammatory support by blocking two key inflammation enzymes: COX-2 and 5-LOX.
09
This version uses very short sentences, everyday wording, and clear cause-and-effect structure for maximum clarity.
Inside the formula
Every ingredient earns its place.
The exact composition of Lorbiotics Atopic Forte — each organism and active listed at its formulated dose.
| Organism / active | Documented role | Dose |
|---|---|---|
| Lactobacillus plantarum | — | 5 B CFU |
| Bifidobacterium lactis | — | 5 B CFU |
| Lactobacillus rhamnosus | — | 5 B CFU |
| Riboflavin | Vitamin B2 | As standardized |
| Prebiotic | — | as standardized |
| Phytoactivants | — | as standardized |
The practical bits
How to take it.
Dosage
Adults & Children (>6 years): 1–2 sachets/capsules daily. Recommended minimum course: 16 weeks for moderate-severe AD. Or as advised by physician / dermatologist.
In the pack
Capsule / Sachet · 60 per Pack
With Riboflavin (Vit B2), prebiotic & phytoactivant blend. Minimum 16-week course recommended for moderate-severe AD.
Certifications
- WHO-GMP
- ISO 13485
- Allergen Free
- Clinical Test
- 24 Month Stability
Note: Not for medicinal use or for curative action. Recommended to use as food supplement only
Reviews
What people say after they've actually taken it.
—
☆☆☆☆☆No reviews yet
☆☆☆☆☆
No reviews yet
Reviews come from verified buyers only. Once customers who've purchased Atopic Forte share their experience, you'll see it here.
Evidence base
Peer-reviewed references.
Every claim on this page traces back to published literature. The full citation list for Lorbiotics Atopic Forte.
- 01Drago L, et al. J Clin Gastroenterol. 2012 46(Suppl):S56-63.
- 02Kalliomaki M, et al. Lancet. 2001 357(9262):1076-9.
- 03Probiotical S.p.A. LPB-DE-ATOPICFORTE · L. plantarum + B. lactis + L. rhamnosus 6B + Riboflavin + Prebiotic + Phytoactivants · 60 Caps
Often paired with
