01
Lactobacillus casei balances the gut-derived IGF-1/insulin axis by enhancing insulin sensitivity and blunting postprandial insulin spikes.
Skin · LPB-DE-003
Lorbiotics · LPB-DE-003
Clinical DomainDermatologyLorbiotics Acne
Clear skin starts in your gut, not just your skincare routine. Clinically studied strains that reduce sebum production and target the inflammation behind persistent acne.
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3Active strains
Capsule / SachetDosage form
- Capsules
- Allergen Free
- In Vitro Test
- Clinical Test
- 24 Month Stability
1
32%
The headline result
32% reduction in facial lesion count and 27% reduction in erythema over 12 weeks with L. casei — validated through IGF-1 modulation and immune regulation of the sebaceous gland.
The science
Why Acne works.
Lorbiotics-Acne is a precision dermatological probiotic designed for mild-to-moderate acne vulgaris. It targets the key microbiological, hormonal, and inflammatory drivers of acne through an inside-out approach.
Key Ingredients
Probiotic strains: Bifidobacterium breve, Lactobacillus casei, and Lactobacillus salivarius
Supporting nutrients: Biotin, N-Acetyl Cysteine (NAC), and a phytoactivant complex
How It Works
Lorbiotics-Acne addresses:
Gut-skin axis disruption — Acne is linked to reduced gut Lactobacillus diversity, leaky gut, and elevated IGF-1, insulin, and pro-inflammatory cytokines that fuel excess sebum and P. acnes (now Cutibacterium acnes) virulence.
Clinical benefits of L. casei — Shown to reduce facial lesions by 32% and erythema by 27% over 12 weeks via IGF-1 modulation and immune regulation of the sebaceous gland.
NAC’s dual action — Acts as a potent antioxidant (boosting glutathione) and mucolytic to neutralize ROS from neutrophil infiltration while downregulating IGF-1/mTORC1 signaling to curb excessive sebum production.
Therapeutic targets
- 01Facial lesion reduction
- 02Sebum secretion normalisation
- 03P. acnes counteraction
- 04Erythema & desquamation reduction
- 05Mild-to-moderate acne management
- 06Antioxidant protection
“Lorbiotics-Acne is a precision dermatological probiotic designed for mild-to-moderate acne vulgaris.”
Lorbiotics Acne · Dermatology
Mechanism of action
How it works, step by step.
The documented biological pathway — exactly how each component acts inside the body.
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These spikes normally activate mTORC1 in sebocytes, driving excess sebum production and comedone formation.
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It also reduces intestinal LPS leakage, thereby limiting TLR-4 activation on sebocytes and downstream pro-inflammatory lipid mediators that fuel sebum overproduction.
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Lactobacillus salivarius produces salivaricin bacteriocins that selectively inhibit P. acnes RNAIII expression - the master regulator of its virulence factors - decreasing secretion of α-toxin, lipase, and proteases that trigger follicular inflammation.
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Bifidobacterium breve complements this by suppressing IL-17A (the key cytokine linking gut dysbiosis to sebaceous inflammation) via induction of regulatory T cells (Tregs) in the gut mucosa.
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Biotin and the phytoactivant blend further support sebum normalization and anti-comedogenic effects by modulating keratinocyte differentiation.
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This multi-targeted mechanism addresses both hormonal/sebum-driven and inflammatory pathways in acne pathogenesis through gut–skin axis modulation.
Inside the formula
Every ingredient earns its place.
The exact composition of Lorbiotics Acne — each organism and active listed at its formulated dose.
| Organism / active | Documented role | Dose |
|---|---|---|
| Bifidobacterium breve | — | 5 B CFU |
| Lactobacillus casei | — | 5 B CFU |
| Lactobacillus salivarius | — | 5 B CFU |
| Biotin | Vitamin B7 | as standardized |
| N-Acetyl Cysteine | NAC | as standardized |
The practical bits
How to take it.
Dosage
1–2 sachets/capsules daily, with meals, for a minimum of 12 weeks. Can be used as adjunct to topical or systemic acne therapy. Or as advised by physician.
In the pack
Capsule / Sachet · 60 per Pack
With Biotin (Vit B7), NAC (N-Acetyl Cysteine) & Phytoactivant complex for antioxidant and sebum-normalising support.
Certifications
- WHO-GMP
- ISO 13485
- Allergen Free
- Clinical Test
- 24 Month Stability
Note: Not for medicinal use or for curative action. Recommended to use as food supplement only
Reviews
What people say after they've actually taken it.
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Reviews come from verified buyers only. Once customers who've purchased Acne share their experience, you'll see it here.
Evidence base
Peer-reviewed references.
Every claim on this page traces back to published literature. The full citation list for Lorbiotics Acne.
- 01Jung GW, et al. J Dermatolog Treat. 2013 24(6):458-62.
- 02Bowe WP, Logan AC. Gut Pathog. 2011 3(1):1.
- 03Probiotical S.p.A. LPB-DE-ACNE · B. breve + L. casei + L. salivarius 5B + Biotin + NAC + Phytoactivants · 60 Caps
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