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Lactobacillus fermentum and L. rhamnosus improve insulin sensitivity in PCOS via two synergistic mechanisms:
Women's · LPB-GY-003
Lorbiotics · LPB-GY-003
Clinical DomainGynaecologyLorbiotics EvaForte Plus
Advanced hormonal and microbiome support for women navigating BV, PCOS, and hormonal transitions. Clinical-grade women's health in a daily sachet.
☆☆☆☆☆No reviews yet16BCFU at expiry · per dose
7Active strains
Capsule / SachetDosage form
- Capsules
- Allergen Free
- In Vitro Test
- Clinical Test
- 24 Month Stability
1
14B
The headline result
CFU across 7 strains targeting the gut-vaginal-hormonal axis in women's health
The science
Why EvaForte Plus works.
Evaforte is an advanced women’s health synbiotic designed for comprehensive support of reproductive-age and perimenopausal urogenital and hormonal health.
It combines six targeted Lactobacillus strains, Bifidobacterium bifidum, FOS prebiotic, and Alpha-Lactalbumin to go beyond simple vaginal microbiome restoration.
Lorbiotics -Evaforte addresses the gut-vaginal-hormonal axis in conditions where dysbiosis plays a key role: PCOS, postmenopausal urogenital atrophy, and recurrent gynaecological infections.
Therapeutic targets
- 01PCOS managementinsulin sensitivity improvement, free testosterone reduction, menstrual cycle restoration
- 02Bacterial vaginosis preventionmulti-species lactic acid and H2O2 production restoring vaginal acid pH
- 03Candidiasis recurrence reductionanti-biofilm and anti-germ tube mechanisms targeting C. albicans
- 04UTI preventionurogenital Lactobacillus barrier reducing UPEC colonisation and ascent
- 05Postmenopausal urogenital supportrestoration of vaginal glycogen metabolism and epithelial trophism
- 06Gut motility & comfortimproved regularity and reduced bloating through SCFA and GLP-1 modulation
“Evaforte is an advanced women’s health synbiotic designed for comprehensive support of reproductive-age and perimenopausal urogenital and hormonal health.”
Lorbiotics EvaForte Plus · Gynaecology
Mechanism of action
How it works, step by step.
The documented biological pathway — exactly how each component acts inside the body.
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SCFA pathway: Production of propionate and butyrate activates FFAR2/FFAR3 on gut enteroendocrine cells, boosting GLP-1 and PYY secretion. This suppresses appetite and lowers hyperinsulinaemia.
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LPS/TLR-4 pathway: Reduced intestinal LPS translocation decreases TLR-4-mediated serine phosphorylation of IRS-1, directly addressing the core molecular driver of insulin resistance in PCOS.
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Together, these effects lower fasting insulin, HOMA-IR, and circulating androgens.
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Key Benefits in PCOS
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PCOS affects 1 in 10 women of reproductive age and involves hyperandrogenism, insulin resistance, inflammation, and irregular cycles.
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The specific strains in Evaforte Plus (L. rhamnosus, L. plantarum, and L. fermentum) have demonstrated clinical ability to:
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Lower free testosterone
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Improve insulin sensitivity
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Restore menstrual regularity
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via microbiome-mediated hormonal recalibration.
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Alpha-Lactalbumin Advantage
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This bioactive whey protein offers dual action:
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Acts as a potent prebiotic with lactulose-like bifidogenic effects, promoting Lactobacillus and Bifidobacterium growth.
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Serves as a rich tryptophan source, supporting serotonin (5-HT) synthesis to help regulate the gut-brain-hormonal axis — easing mood issues and appetite dysregulation common in PCOS and perimenopause.
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Evaforte has targeted synbiotic support for the gut-vaginal-hormonal connection in women’s health.
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Additional benefits of the formulation:
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FOS prebiotic enhances Lactobacillus colonisation at intestinal and vaginal sites, increasing lactic acid and H₂O₂ production for sustained vaginal defence.
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Bifidobacterium bifidum regulates oestrogen enterohepatic recirculation via β-glucuronidase activity, helping maintain optimal free oestrogen levels for endometrial health, bone density, and cardiovascular protection in perimenopausal women.
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In postmenopausal women, the Lactobacillus strains restore vaginal epithelial glycogen metabolism, supporting lactic acid production and countering oestrogen-loss-induced vaginal atrophy and pH rise.
Inside the formula
Every ingredient earns its place.
The exact composition of Lorbiotics EvaForte Plus — each organism and active listed at its formulated dose.
| Organism / active | Documented role | Dose |
|---|---|---|
| Lactobacillus acidophilus | — | 2 B CFU |
| Lactobacillus rhamnosus | — | 2 B CFU |
| Lactobacillus reuteri | — | 2 B CFU |
| Lactobacillus plantarum | — | 2 B CFU |
| Lactobacillus casei | — | 2 B CFU |
| Lactobacillus fermentum | — | 2 B CFU |
| Bifidobacterium bifidum | — | 2 B CFU |
| FOS Prebiotic -as standardized | — | — |
| Alpha-Lactalbumin | — | as standardized |
The practical bits
How to take it.
Dosage
1–2 sachets/capsules daily with meals. For PCOS: minimum 16-week course recommended. For gynaecological infection prevention: long-term daily use. Or as advised by gynaecologist / endocrinologist / physician.
In the pack
Capsule / Sachet · 60 per Pack
14 Billion CFU | 7 strains + FOS prebiotic & Alpha-Lactalbumin
Certifications
- WHO-GMP
- ISO 13485
- Allergen Free
- Clinical Test
- 24 Month Stability
Note: Not for medicinal use or for curative action. Recommended to use as food supplement only
Reviews
What people say after they've actually taken it.
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Reviews come from verified buyers only. Once customers who've purchased EvaForte Plus share their experience, you'll see it here.
Evidence base
Peer-reviewed references.
Every claim on this page traces back to published literature. The full citation list for Lorbiotics EvaForte Plus.
- 01Heczko PB, et al. Supplementation of standard antibiotic therapy with oral probiotics for bacterial vaginosis and aerobic vaginitis: a randomised, double-blind, placebo-controlled trial. BMC Womens Health. 2015 15:115
- 02Cosola C, et al. Beta-glucans supplementation associates with reduction in P-cresyl sulfate levels and improved endothelial vascular reactivity in healthy individuals. PLoS One. 2017 12(1):e0169635
- 03Karamali M, et al. The effects of synbiotic supplementation on glucose metabolism and lipid profiles in patients with polycystic ovary syndrome. Horm Metab Res. 2018 50(4):271–9
- 04Probiotical S.p.A. Clinically Tested Dossier 2023. LPB-GY-0050 · Evaforte Plus · 14B CFU 7-strain blend + FOS + Alpha-Lactalbumin · 30 Caps / Sachet
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